human ACACA shRNA silencing Adenovirus
This is an Adenovirus expressing shRNA for silencing of Human ACACA.
shADV-200146
Ad-h-ACACA-shRNA
Ready-to-use Adenovirus expressing shRNA for silencing of Human ACACA (acetyl-CoA carboxylase alpha). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
ACAC; ACACAD; ACC; ACC1; ACCA; ACC-alpha; acetyl-CoA carboxylase 1; acetyl-Coenzyme A carboxylase alpha; Biotin carboxylase
Description (eCommerce)
ACC1/ACC-alpha catalyzes the carboxylation of acetyl-CoA to malonyl-CoA in the enzymatic pathway of long-chain fatty-acid synthesis. ACC1/ACC-alpha has been identified as a partner of BRCA1. Through this interaction, ACC1/ACC-alpha may contribute to the tumor suppressor activity of BRCA1 as demonstrated by the finding that disruption of this interaction increases lipid synthesis in mammary epithelial cells. In this context, lipogenesis has been closely linked to tumorigenesis and ACC1/ACC-alpha has been found to be highly expressed in human breast carcinomas.
Description (Vector)
Acetyl-CoA carboxylase (ACC) is a complex multifunctional enzyme system. ACC is a biotin-containing enzyme which catalyzes the carboxylation of acetyl-CoA to malonyl-CoA, the rate-limiting step in fatty acid synthesis. There are two ACC forms, alpha and beta, encoded by two different genes. ACC-alpha is highly enriched in lipogenic tissues. The enzyme is under long term control at the transcriptional and translational levels and under short term regulation by the phosphorylation/dephosphorylation of targeted serine residues and by allosteric transformation by citrate or palmitoyl-CoA. Multiple alternatively spliced transcript variants divergent in the 5' sequence and encoding distinct isoforms have been found for this gene.
Gene ID
31
Gene Name (eCommerce)
acetyl-CoA carboxylase alpha
Gene Name (Vector)
acetyl-CoA carboxylase alpha
Gene Symbol
ACACA
HGNC ID
HGNC:84
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
7152
ORF Size (bp)
7152 bp
Protein Name (eCommerce)
Acetyl-CoA carboxylase 1
RefSeq ID
NM_198834
RefSeq Synonyms
NM_198839, NM_198838, NM_198837, NM_198836, NM_198834, BC137287,
Research Areas
Insulin Signaling,Leptin Signaling,Metabolism/Metabolic Process,Mitochondrion,Signal Transduction
Research Areas (Faceted)
cell_biology,metabolism,signal_transduction
Species
human
Target Sentence
ACC1/ACC-alpha catalyzes the carboxylation of acetyl-CoA to malonyl-CoA in the enzymatic pathway of long-chain fatty-acid synthesis. ACC1/ACC-alpha has been identified as a partner of BRCA1. Through this interaction, ACC1/ACC-alpha may contribute to the tumor suppressor activity of BRCA1 as demonstrated by the finding that disruption of this interaction increases lipid synthesis in mammary epithelial cells. In this context, lipogenesis has been closely linked to tumorigenesis and ACC1/ACC-alpha has been found to be highly expressed in human breast carcinomas.
UniGene ID
Hs.160556
UniProt ID (eCommerce)
Q13085
Recently Viewed Products
AAV-m-ATOH1
Cat No: AAV-253239
AAV-m-ACAD10-shRNA
Cat No: shAAV-251874
Ad-h-ACTL8-shRNA
Cat No: shADV-200298
About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.