human ABCB4 shRNA silencing Adenovirus
This is an Adenovirus expressing shRNA for silencing of Human ABCB4.
shADV-200058
Ad-h-ABCB4-shRNA
Ready-to-use Adenovirus expressing shRNA for silencing of Human ABCB4 (ATP binding cassette subfamily B member 4). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
ABC21; GBD1; ICP3; MDR2; MDR2/3; MDR3; PFIC-3; PGY3
Description (Vector)
The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MDR/TAP subfamily. Members of the MDR/TAP subfamily are involved in multidrug resistance as well as antigen presentation. This gene encodes a full transporter and member of the p-glycoprotein family of membrane proteins with phosphatidylcholine as its substrate. The function of this protein has not yet been determined; however, it may involve transport of phospholipids from liver hepatocytes into bile. Alternative splicing of this gene results in several products of undetermined function.
Gene ID
5244
Gene Name (Vector)
ATP binding cassette subfamily B member 4
Gene Symbol
ABCB4
HGNC ID
HGNC:45
ORF Size (aa)
3861
ORF Size (bp)
3861 bp
RefSeq ID
NM_000443
RefSeq Synonyms
NM_018850, NM_018849, NM_000443, BC042531,
Species
human
UniGene ID
Hs.654403
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About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.