human JMY Over-expression AAV

Name 
AAV-h-JMY
Cat No 
AAV-212587
Availability
4-5 weeks
Categories
AAV, Over-Expression

This is an AAV expressing Human JMY.

AAV-212587
AAV-h-JMY

Ready-to-use AAV expressing Human JMY (junction mediating and regulatory protein, p53 cofactor). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype
Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
AAV ITR
AAV2
Promoter
CMV (default), or choose from 30 different ubiquitous or cell specific promoter
Reporter
none, optional GFP, CFP, YFP, RFP or mCherry
Storage Buffer
PBS/5% Glycerol
Viral Backbone
Recombinant AAV

Gene Reference Data

Alternate Names
junction-mediating and -regulatory protein; WAS protein homology region 2 domain containing 1-like 3; WHAMM2; WHDC1L3
Description (eCommerce)
Junction-mediating and -regulatory protein (JMY) acts both as a nuclear p53/TP53-cofactor and a cytoplasmic regulator of actin dynamics depending on conditions. In the nucleus, JMY acts as a cofactor that increases p53/TP53 response via its interaction with p300/EP300 and increases p53/TP53-dependent transcription and apoptosis suggesting an important role in p53/TP53 stress response such as DNA damage. In the cytoplasm, JMY acts as a nucleation-promoting factor for both branched and un-branched actin filaments. It activates the Arp2/3 complex to induce branched actin filament networks and also catalyzes actin polymerization in the absence of Arp2/3, creating un-branched filaments [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/Q8N9B5].
Gene ID
133746
Gene Name (eCommerce)
junction mediating and regulatory protein, p53 cofactor
Gene Name (Vector)
junction mediating and regulatory protein, p53 cofactor
Gene Symbol
JMY
HGNC ID
HGNC:28916
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
1869
ORF Size (bp)
1869 bp
Protein Name (eCommerce)
Junction-mediating and -regulatory protein
RefSeq ID
NM_152405
RefSeq Synonyms
NM_152405, BC130624,
Research Areas
Apoptosis,Cell Cycle,Cytoskeleton,DNA Damage/Repair
Research Areas (Faceted)
cell_biology,cell_cycle,genetics,transcription_translation
Species
human
Target Sentence
Junction-mediating and -regulatory protein (JMY) acts both as a nuclear p53/TP53-cofactor and a cytoplasmic regulator of actin dynamics depending on conditions. In the nucleus, JMY acts as a cofactor that increases p53/TP53 response via its interaction with p300/EP300 and increases p53/TP53-dependent transcription and apoptosis suggesting an important role in p53/TP53 stress response such as DNA damage. In the cytoplasm, JMY acts as a nucleation-promoting factor for both branched and un-branched actin filaments. It activates the Arp2/3 complex to induce branched actin filament networks and also catalyzes actin polymerization in the absence of Arp2/3, creating un-branched filaments [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/Q8N9B5].
UniGene ID
Hs.482605
UniProt ID (eCommerce)
Q8N9B5

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.