rat NSMCE1 shRNA silencing AAV

Name
AAV-r-NSMCE1-shRNA

Cat No
shAAV-294413

Availability
4-5 weeks

This is an AAV expressing shRNA for silencing of Rat Nsmce1.

shAAV-294413

AAV-r-NSMCE1-shRNA

Ready-to-use AAV expressing shRNA for silencing of Rat Nsmce1 (NSE1 homolog, SMC5-SMC6 complex component). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype

Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids

AAV ITR

AAV2

Promoter

U6 ()

Reporter

eGFP (default), optional CFP, YFP, RFP, mCherry

shRNA Knockdown (%)

Storage Buffer

PBS/5% Glycerol

Viral Backbone

Recombinant AAV

Gene Reference Data

Alternate Names

RGD1307760

Description (Vector)

Component of the SMC5-SMC6 complex, a complex involved in DNA double-strand breaks by homologous recombination. The complex may promote sister chromatid homologous recombination by recruiting the SMC1-SMC3 cohesin complex to double-strand breaks. The complex is required for telomere maintenance via recombination in ALT (alternative lengthening of telomeres) cell lines and mediates sumoylation of shelterin complex (telosome) components which is proposed to lead to shelterin complex disassembly in ALT-associated PML bodies (APBs). Has in vitro ubiquitin ligase activity in presence of NDNL2. Is involved in positive regulation of response to DNA damage stimulus.

Gene ID

361645

Gene Name (Vector)

NSE1 homolog, SMC5-SMC6 complex component

Gene Symbol

Nsmce1

ORF Size (aa)

873

ORF Size (bp)

873 bp

RefSeq ID

NM_001039611

RefSeq Synonyms

NM_001039611, BC099757,

Species

rat

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.