rat A2M shRNA silencing AAV
This is an AAV expressing shRNA for silencing of Rat A2m.
shAAV-294270
AAV-r-A2M-shRNA
Ready-to-use AAV expressing shRNA for silencing of Rat A2m (alpha-2-macroglobulin). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
A2m1; A2maa; A2MAC1; A2mb; Mam
Description (Vector)
Is able to inhibit all four classes of proteinases by a unique 'trapping' mechanism. This protein has a peptide stretch, called the 'bait region' which contains specific cleavage sites for different proteinases. When a proteinase cleaves the bait region, a conformational change is induced in the protein which traps the proteinase. The entrapped enzyme remains active against low molecular weight substrates (activity against high molecular weight substrates is greatly reduced). Following cleavage in the bait region a thioester bond is hydrolyzed and mediates the covalent binding of the protein to the proteinase.
Gene ID
24153
Gene Name (Vector)
alpha-2-macroglobulin
Gene Symbol
A2m
ORF Size (aa)
4419
ORF Size (bp)
4419 bp
RefSeq ID
NM_012488
RefSeq Synonyms
NM_012488, BC098922,
Species
rat
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About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.