rat ARHGEF1 shRNA silencing AAV

Name
AAV-r-ARHGEF1-shRNA

Cat No
shAAV-293395

Availability
6-8 weeks

This is an AAV expressing shRNA for silencing of Rat Arhgef1.

shAAV-293395

AAV-r-ARHGEF1-shRNA

Ready-to-use AAV expressing shRNA for silencing of Rat Arhgef1 (Rho guanine nucleotide exchange factor 1). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype

Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids

AAV ITR

AAV2

Promoter

U6 ()

Reporter

eGFP (default), optional CFP, YFP, RFP, mCherry

Storage Buffer

PBS/5% Glycerol

Viral Backbone

Recombinant AAV

Gene Reference Data

Alternate Names

Lsc

Description (Vector)

Seems to play a role in the regulation of RhoA GTPase by guanine nucleotide-binding alpha-12 (GNA12) and alpha-13 (GNA13) subunits. Acts as GTPase-activating protein (GAP) for GNA12 and GNA13, and as guanine nucleotide exchange factor (GEF) for RhoA GTPase. Activated G alpha 13/GNA13 stimulates the RhoGEF activity through interaction with the RGS-like domain. This GEF activity is inhibited by binding to activated GNA12. Mediates angiotensin-2-induced RhoA activation.

Gene ID

60323

Gene Name (Vector)

Rho guanine nucleotide exchange factor 1

Gene Symbol

Arhgef1

ORF Size (aa)

2760

ORF Size (bp)

2760 bp

RefSeq ID

NM_021694

RefSeq Synonyms

NM_021694, BC091218,

Species

rat

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.