rat RNF5 shRNA silencing AAV
This is an AAV expressing shRNA for silencing of Rat Rnf5.
shAAV-292898
AAV-r-RNF5-shRNA
Ready-to-use AAV expressing shRNA for silencing of Rat Rnf5 (ring finger protein 5). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Description (Vector)
Has E2-dependent E3 ubiquitin-protein ligase activity. May function together with E2 ubiquitin-conjugating enzymes UBE2D1/UBCH5A and UBE2D2/UBC4. Mediates ubiquitination of PXN/paxillin and Salmonella type III secreted protein sopA. May be involved in regulation of cell motility and localization of PXN/paxillin. Mediates the 'Lys-63'-linked polyubiquitination of JKAMP thereby regulating JKAMP function by decreasing its association with components of the proteasome and ERAD; the ubiquitination appears to involve E2 ubiquitin-conjugating enzyme UBE2N. Mediates the 'Lys-48'-linked polyubiquitination of TMEM173 at 'Lys-150' leading to its proteasomal degradation; the ubiquitination occurrs in mitochondria after viral transfection and regulates antiviral responses.
Gene ID
407784
Gene Name (Vector)
ring finger protein 5
Gene Symbol
Rnf5
ORF Size (aa)
543
RefSeq ID
NM_001109025
RefSeq Synonyms
NM_001109025, BC088341,
Species
rat
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About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.