rat FAIM3 shRNA silencing AAV

Name
AAV-r-FAIM3-shRNA

Cat No
shAAV-292771

Availability
6-8 weeks

This is an AAV expressing shRNA for silencing of Rat Fcmr.

shAAV-292771

AAV-r-FAIM3-shRNA

Ready-to-use AAV expressing shRNA for silencing of Rat Fcmr (Fc fragment of IgM receptor). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype

Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids

AAV ITR

AAV2

Promoter

U6 ()

Reporter

eGFP (default), optional CFP, YFP, RFP, mCherry

Storage Buffer

PBS/5% Glycerol

Viral Backbone

Recombinant AAV

Gene Reference Data

Alternate Names

Faim3; Toso

Description (Vector)

FAIM3 may play a role in the immune system processes. Protects cells from FAS-, TNF alpha- and FADD-induced apoptosis without increasing expression of the inhibitors of apoptosis BCL2 and BCLXL. Seems to activate an inhibitory pathway that prevents CASP8 activation following FAS stimulation, rather than blocking apoptotic signals downstream. May inhibit FAS-induced apoptosis by preventing CASP8 processing through CFLAR up-regulation.

Gene ID

548326

Gene Name (Vector)

Fc fragment of IgM receptor

Gene Symbol

Fcmr

ORF Size (aa)

1281

ORF Size (bp)

1281 bp

RefSeq ID

NM_001014843

RefSeq Synonyms

NM_001014843, BC088197,

Species

rat

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.