human IL9 Over-expression AAV

Name 
AAV-h-IL9
Cat No 
AAV-212216
Availability
4-5 weeks
Categories
AAV, Over-Expression

This is an AAV expressing Human IL9.

AAV-212216
AAV-h-IL9

Ready-to-use AAV expressing Human IL9 (interleukin 9). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype
Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
AAV ITR
AAV2
Promoter
CMV (default), or choose from 30 different ubiquitous or cell specific promoter
Reporter
none, optional GFP, CFP, YFP, RFP or mCherry
Storage Buffer
PBS/5% Glycerol
Viral Backbone
Recombinant AAV

Gene Reference Data

Alternate Names
cytokine P40;homolog of mouse T cell and mast cell growth factor 40;HP40;IL-9;interleukin-9;P40;p40 cytokine;p40 T-cell and mast cell growth factor;T-cell growth factor p40
Description (eCommerce)
Interleukin 9 is a multifunctional cytokine secreted mainly by T-helper 2 lymphocytes and also mast cells or NKT cells that plays important roles in the immune response against parasites. IL-9 induces the differentiation of specific T-cell subsets such as IL-17 producing helper T-cells (TH17) and also proliferation and differentiation of mast cells. Mechanistically, IL9 exerts its biological effects through a receptor composed of IL9R subunit and a signal transducing subunit IL2RG. Receptor stimulation results in the rapid activation of JAK - STAT pathways. [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/P15248].
Description (Vector)
IL9 is a cytokine that acts as a regulator of a variety of hematopoietic cells. This cytokine stimulates cell proliferation and prevents apoptosis. It functions through the interleukin 9 receptor (IL9R), which activates different signal transducer and activator (STAT) proteins and thus connects this cytokine to various biological processes. The gene encoding this cytokine has been identified as a candidate gene for asthma. Genetic studies on a mouse model of asthma demonstrated that this cytokine is a determining factor in the pathogenesis of bronchial hyperresponsiveness.
Gene ID
3578
Gene Name (eCommerce)
interleukin 9
Gene Name (Vector)
interleukin 9
Gene Symbol
IL9
HGNC ID
HGNC:6029
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
435
Protein Name (eCommerce)
Interleukin-9
RefSeq ID
NM_000590
RefSeq Synonyms
NM_000590, BC066287, BC066286, BC066285, BC066284, BC066283,
Research Areas (Faceted)
immunology,signal_transduction
Species
human
Target Sentence
Interleukin 9 is a multifunctional cytokine secreted mainly by T-helper 2 lymphocytes and also mast cells or NKT cells that plays important roles in the immune response against parasites. IL-9 induces the differentiation of specific T-cell subsets such as IL-17 producing helper T-cells (TH17) and also proliferation and differentiation of mast cells. Mechanistically, IL9 exerts its biological effects through a receptor composed of IL9R subunit and a signal transducing subunit IL2RG. Receptor stimulation results in the rapid activation of JAK - STAT pathways. [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/P15248].
UniGene ID
Hs.960
UniProt ID (eCommerce)
P15248

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.