rat TNFRSF11B shRNA silencing AAV
This is an AAV expressing shRNA for silencing of Rat Tnfrsf11b.
shAAV-291809
AAV-r-TNFRSF11B-shRNA
Ready-to-use AAV expressing shRNA for silencing of Rat Tnfrsf11b (TNF receptor superfamily member 11B). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
Opg
Description (Vector)
Acts as decoy receptor for RANKL and thereby neutralizes its function in osteoclastogenesis. Inhibits the activation of osteoclasts and promotes osteoclast apoptosis in vitro. Bone homeostasis seems to depend on the local RANKL/OPG ratio. May also play a role in preventing arterial calcification. May act as decoy receptor for TRAIL and protect against apoptosis. TRAIL binding blocks the inhibition of osteoclastogenesis.
Gene ID
25341
Gene Name (Vector)
TNF receptor superfamily member 11B
Gene Symbol
Tnfrsf11b
ORF Size (aa)
1206
ORF Size (bp)
1206 bp
RefSeq ID
NM_012870
RefSeq Synonyms
NM_012870, BC081830,
Species
rat
About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.