human IL12RB2 Over-expression AAV

Name 
AAV-h-IL12RB2
Cat No 
AAV-212037
Availability
4-5 weeks
Categories
AAV, Over-Expression

This is an AAV expressing Human IL12RB2.

AAV-212037
AAV-h-IL12RB2

Ready-to-use AAV expressing Human IL12RB2 (interleukin 12 receptor subunit beta 2). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype
Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
AAV ITR
AAV2
Promoter
CMV (default), or choose from 30 different ubiquitous or cell specific promoter
Reporter
none, optional GFP, CFP, YFP, RFP or mCherry
Storage Buffer
PBS/5% Glycerol
Viral Backbone
Recombinant AAV

Gene Reference Data

Description (Vector)
IL12RB2 is a type I transmembrane protein identified as a subunit of the interleukin 12 receptor complex. The coexpression of this and IL12RB1 proteins was shown to lead to the formation of high-affinity IL12 binding sites and reconstitution of IL12 dependent signaling. The expression of this gene is up-regulated by interferon gamma in Th1 cells, and plays a role in Th1 cell differentiation. The up-regulation of this gene is found to be associated with a number of infectious diseases, such as Crohn's disease and leprosy, which is thought to contribute to the inflammatory response and host defense. Several transcript variants encoding different isoforms and non-protein coding transcripts have been found for this gene.
Gene ID
3595
Gene Name (Vector)
interleukin 12 receptor subunit beta 2
Gene Symbol
IL12RB2
HGNC ID
HGNC:5972
ORF Size (aa)
2331
ORF Size (bp)
2331 bp
RefSeq ID
NM_001559
RefSeq Synonyms
NM_001559, NM_001319233, NM_001258216, NM_001258215, NM_001258214, BC143249, BC104774, BC104772,
Species
human
UniGene ID
Hs.479347

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About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.