rat GLRX2 shRNA silencing AAV
This is an AAV expressing shRNA for silencing of Rat Glrx2.
shAAV-291557
AAV-r-GLRX2-shRNA
Ready-to-use AAV expressing shRNA for silencing of Rat Glrx2 (glutaredoxin 2). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Description (Vector)
Glutathione-dependent oxidoreductase that facilitates the maintenance of mitochondrial redox homeostasis upon induction of apoptosis by oxidative stress. Involved in response to hydrogen peroxide and regulation of apoptosis caused by oxidative stress. Acts as a very efficient catalyst of monothiol reactions because of its high affinity for protein glutathione-mixed disulfides. Can receive electrons not only from glutathione (GSH), but also from thioredoxin reductase supporting both monothiol and dithiol reactions. Efficiently catalyzes both glutathionylation and deglutathionylation of mitochondrial complex I, which in turn regulates the superoxide production by the complex. Overexpression decreases the susceptibility to apoptosis and prevents loss of cardiolipin and cytochrome c release.
Gene ID
114022
Gene Name (Vector)
glutaredoxin 2
Gene Symbol
Glrx2
ORF Size (aa)
375
RefSeq ID
NM_001013034
RefSeq Synonyms
NM_001013034, BC079292,
Species
rat
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About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.