mouse CDH1 shRNA silencing AAV

Name
AAV-m-CDH1-shRNA

Cat No
shAAV-280631

Availability
6-8 weeks

This is an AAV expressing shRNA for silencing of Mouse Cdh1.

shAAV-280631

AAV-m-CDH1-shRNA

Ready-to-use AAV expressing shRNA for silencing of Mouse Cdh1 (cadherin 1). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype

Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids

AAV ITR

AAV2

Promoter

U6 ()

Reporter

eGFP (default), optional CFP, YFP, RFP, mCherry

Storage Buffer

PBS/5% Glycerol

Viral Backbone

Recombinant AAV

Gene Reference Data

Alternate Names

AA960649; ARC-1; E-cad; Ecad; L-CAM; Um; UVO

Description (Vector)

Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. CDH1 is involved in mechanisms regulating cell-cell adhesions, mobility and proliferation of epithelial cells. Has a potent invasive suppressor role. It is a ligand for integrin alpha-E/beta-7|Function: E-Cad/CTF2 promotes non-amyloidogenic degradation of Abeta precursors. Has a strong inhibitory effect on APP C99 and C83 production.

Gene ID

12550

Gene Name (Vector)

cadherin 1

Gene Symbol

Cdh1

ORF Size (aa)

2655

ORF Size (bp)

2655 bp

RefSeq ID

NM_009864

RefSeq Synonyms

NM_009864, BC098501,

Species

mouse

UniGene ID

Mm.35605

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.