mouse CASC5 shRNA silencing AAV
This is an AAV expressing shRNA for silencing of Mouse Knl1.
shAAV-280612
AAV-m-CASC5-shRNA
Ready-to-use AAV expressing shRNA for silencing of Mouse Knl1 (kinetochore scaffold 1). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
2310043D08Rik; 5730505K17Rik; Casc5
Description (Vector)
Performs two crucial functions during mitosis: it is essential for spindle-assembly checkpoint signaling and for correct chromosome alignment. Required for attachment of the kinetochores to the spindle microtubules. Directly links BUB1 and BUB1B to kinetochores. Part of the MIS12 complex, which may be fundamental for kinetochore formation and proper chromosome segregation during mitosis. Acts in coordination with CENPK to recruit the NDC80 complex to the outer kinetochore.
Gene ID
76464
Gene Name (Vector)
kinetochore scaffold 1
Gene Symbol
Knl1
ORF Size (aa)
4839
ORF Size (bp)
4839 bp
RefSeq ID
NM_029617
RefSeq Synonyms
NM_029617, BC080815,
Species
mouse
UniGene ID
Mm.202518
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About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.