mouse VRK1 shRNA silencing AAV
This is an AAV expressing shRNA for silencing of Mouse Vrk1.
shAAV-276081
AAV-m-VRK1-shRNA
Ready-to-use AAV expressing shRNA for silencing of Mouse Vrk1 (vaccinia related kinase 1). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
51PK
Description (Vector)
Serine/threonine kinase involved in Golgi disassembly during the cell cycle: following phosphorylation by PLK3 during mitosis, required to induce Golgi fragmentation. Acts by mediating phosphorylation of downstream target protein. Phosphorylates 'Thr-18' of p53/TP53 and may thereby prevent the interaction between p53/TP53 and MDM2. Phosphorylates casein and histone H3. Phosphorylates BANF1: disrupts its ability to bind DNA, reduces its binding to LEM domain-containing proteins and causes its relocalization from the nucleus to the cytoplasm.
Gene ID
22367
Gene Name (Vector)
vaccinia related kinase 1
Gene Symbol
Vrk1
ORF Size (aa)
1191
ORF Size (bp)
1191 bp
RefSeq ID
NM_011705
RefSeq Synonyms
NM_011705, NM_001029844, NM_001029843, BC016676,
Species
mouse
UniGene ID
Mm.2981
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About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.