mouse VAV3 shRNA silencing AAV
This is an AAV expressing shRNA for silencing of Mouse Vav3.
shAAV-275976
AAV-m-VAV3-shRNA
Ready-to-use AAV expressing shRNA for silencing of Mouse Vav3 (vav 3 oncogene). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
A530094I06Rik; AA986410; Idd18.1
Description (Vector)
Exchange factor for GTP-binding proteins RhoA, RhoG and, to a lesser extent, Rac1. Binds physically to the nucleotide-free states of those GTPases. Plays an important role in angiogenesis. Its recruitement by phosphorylated EPHA2 is critical for EFNA1-induced RAC1 GTPase activation and vascular endothelial cell migration and assembly (By similarity). May be important for integrin-mediated signaling, at least in some cell types. In osteoclasts, along with SYK tyrosine kinase, required for signaling through integrin alpha-v/beta-1 (ITAGV-ITGB1), a crucial event for osteoclast proper cytoskeleton organization and function. This signaling pathway involves RAC1, but not RHO, activation. Necessary for proper wound healing. In the course of wound healing, required for the phagocytotic cup formation preceding macrophage phagocytosis of apoptotic neutrophils. Responsible for integrin beta-2 (ITGB2)-mediated macrophage adhesion and, to a lesser extent, contributes to beta-3 (ITGB3)-mediated adhesion. Does not affect integrin beta-1 (ITGB1)-mediated adhesion (By similarity).
Gene ID
57257
Gene Name (Vector)
vav 3 oncogene
Gene Symbol
Vav3
ORF Size (aa)
2544
ORF Size (bp)
2544 bp
RefSeq ID
NM_146139
RefSeq Synonyms
NM_146139, NM_020505, BC052739,
Species
mouse
UniGene ID
Mm.282257
Recently Viewed Products
Ad-m-OLFR292
Cat No: ADV-266978
Ad-m-TAGLN3
Cat No: ADV-273676
AAV-m-OLFR292
Cat No: AAV-266978
Ad-m-SMAP2
Cat No: ADV-272608
About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.