mouse USP2 shRNA silencing AAV

Name
AAV-m-USP2-shRNA

Cat No
shAAV-275720

Availability
4-5 weeks

This is an AAV expressing shRNA for silencing of Mouse Usp2.

shAAV-275720

AAV-m-USP2-shRNA

Ready-to-use AAV expressing shRNA for silencing of Mouse Usp2 (ubiquitin specific peptidase 2). Available with optional GFP reporter or cell-specific promoter.

Request a Quote

Product Details

AAV Serotype

Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids

AAV ITR

AAV2

Promoter

U6 ()

Reporter

eGFP (default), optional CFP, YFP, RFP, mCherry

shRNA Knockdown (%)

Storage Buffer

PBS/5% Glycerol

Viral Backbone

Recombinant AAV

Gene Reference Data

Alternate Names

B930035K21Rik; Ubp41

Description (Vector)

Hydrolase that deubiquitinates polyubiquitinated target proteins such as MDM2, MDM4 and CCND1. Isoform 1 and isoform 4 possess both ubiquitin-specific peptidase and isopeptidase activities. Deubiquitinates MDM2 without reversing MDM2-mediated p53/TP53 ubiquitination and thus indirectly promotes p53/TP53 degradation and limits p53 activity. Has no deubiquitinase activity against p53/TP53. Prevents MDM2-mediated degradation of MDM4. Plays a role in the G1/S cell-cycle progression in normal and cancer cells. Plays a role in the regulation of myogenic differentiation of embryonic muscle cells.

Gene ID

53376

Gene Name (Vector)

ubiquitin specific peptidase 2

Gene Symbol

Usp2

ORF Size (aa)

1860

ORF Size (bp)

1860 bp

RefSeq ID

NM_016808

RefSeq Synonyms

NM_198092, NM_198091, NM_016808, BC017517,

Species

mouse

UniGene ID

Mm.272770

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.