mouse UNC13D shRNA silencing AAV
This is an AAV expressing shRNA for silencing of Mouse Unc13d.
shAAV-275633
AAV-m-UNC13D-shRNA
Ready-to-use AAV expressing shRNA for silencing of Mouse Unc13d (unc-13 homolog D (C. elegans)). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
2610108D09Rik; Jinx; mFLJ00067; Munc13-4
Description (Vector)
Plays a role in cytotoxic granule exocytosis in lymphocytes. Required for both granule maturation and granule docking and priming at the immunologic synapse. Regulates assembly of recycling and late endosomal structures, leading to the formation of an endosomal exocytic compartment that fuses with perforin-containing granules at the immunologic synapse and licences them for exocytosis. Regulates Ca(2+)-dependent secretory lysosome exocytosis in mast cells.
Gene ID
70450
Gene Name (Vector)
unc-13 homolog D (C. elegans)
Gene Symbol
Unc13d
ORF Size (aa)
3252
ORF Size (bp)
3252 bp
RefSeq ID
NM_001009573
RefSeq Synonyms
NM_001009573, BC141289,
Species
mouse
UniGene ID
Mm.259460
About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.