human HLA-DPA1 Over-expression AAV
This is an AAV expressing Human HLA-DPA1.
AAV-211216
AAV-h-HLA-DPA1
Ready-to-use AAV expressing Human HLA-DPA1 (major histocompatibility complex, class II, DP alpha 1). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
DP(W3); DP(W4); HLA-DP1A; HLADP; HLASB; PLT1
Description (Vector)
HLA-DPA1 belongs to the HLA class II alpha chain paralogues. This class II molecule is a heterodimer consisting of an alpha (DPA) and a beta (DPB) chain, both anchored in the membrane. It plays a central role in the immune system by presenting peptides derived from extracellular proteins. Class II molecules are expressed in antigen presenting cells (APC: B lymphocytes, dendritic cells, macrophages). The alpha chain is approximately 33-35 kDa and its gene contains 5 exons. Exon one encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, exon 4 encodes the transmembrane domain and the cytoplasmic tail. Within the DP molecule both the alpha chain and the beta chain contain the polymorphisms specifying the peptide binding specificities, resulting in up to 4 different molecules.
Gene ID
3113
Gene Name (Vector)
major histocompatibility complex, class II, DP alpha 1
Gene Symbol
HLA-DPA1
HGNC ID
HGNC:4938
ORF Size (aa)
783
ORF Size (bp)
783 bp
RefSeq ID
NM_033554
RefSeq Synonyms
NM_033554, NM_001242525, NM_001242524, BC009956,
Species
human
UniGene ID
Hs.347270
About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.