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human HLA-DMB Over-expression AAV

Name 
AAV-h-HLA-DMB
Cat No 
AAV-211213
Availability
4-5 weeks
Categories
AAV, Over-Expression

This is an AAV expressing Human HLA-DMB.

AAV-211213
AAV-h-HLA-DMB

Ready-to-use AAV expressing Human HLA-DMB (major histocompatibility complex, class II, DM beta). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype
Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
AAV ITR
AAV2
Promoter
CMV (default), or choose from 30 different ubiquitous or cell specific promoter
Reporter
none, optional GFP, CFP, YFP, RFP or mCherry
Storage Buffer
PBS/5% Glycerol
Viral Backbone
Recombinant AAV

Gene Reference Data

Alternate Names
D6S221E; RING7
Description (Vector)
HLA-DMB belongs to the HLA class II beta chain paralogues. This class II molecule is a heterodimer consisting of an alpha (DMA) and a beta (DMB) chain, both anchored in the membrane. It is located in intracellular vesicles. DM plays a central role in the peptide loading of MHC class II molecules by helping to release the CLIP (class II-associated invariant chain peptide) molecule from the peptide binding site. Class II molecules are expressed in antigen presenting cells (APC: B lymphocytes, dendritic cells, macrophages). The beta chain is approximately 26-28 kDa and its gene contains 6 exons. Exon one encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, exon 4 encodes the transmembrane domain and exon 5 encodes the cytoplasmic tail.
Gene ID
3109
Gene Name (Vector)
major histocompatibility complex, class II, DM beta
Gene Symbol
HLA-DMB
HGNC ID
HGNC:4935
ORF Size (aa)
792
ORF Size (bp)
792 bp
RefSeq ID
NM_002118
RefSeq Synonyms
NM_002118, BC027175,
Species
human
UniGene ID
Hs.654428

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.