mouse SOCS3 shRNA silencing AAV
This is an AAV expressing shRNA for silencing of Mouse Socs3.
shAAV-272833
AAV-m-SOCS3-shRNA
Ready-to-use AAV expressing shRNA for silencing of Mouse Socs3 (suppressor of cytokine signaling 3). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
Cis3; Cish3; EF-10; Ef10; SSI-3; Ssi3
Description (Vector)
SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. SOCS3 is involved in negative regulation of cytokines that signal through the JAK/STAT pathway. Inhibits cytokine signal transduction by binding to tyrosine kinase receptors including gp130, LIF, erythropoietin, insulin, IL12, GCSF and leptin receptors. Binding to JAK2 inhibits its kinase activity. Suppresses fetal liver erythropoiesis. Regulates onset and maintenance of allergic responses mediated by T-helper type 2 cells. Regulates IL-6 signaling in vivo (By similarity). Probable substrate recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Seems to recognize IL6ST (By similarity).
Gene ID
12702
Gene Name (Vector)
suppressor of cytokine signaling 3
Gene Symbol
Socs3
ORF Size (aa)
678
RefSeq ID
NM_007707
RefSeq Synonyms
NM_007707, BC052031,
Species
mouse
UniGene ID
Mm.3468
About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.