mouse SNCB shRNA silencing AAV
This is an AAV expressing shRNA for silencing of Mouse Sncb.
shAAV-272719
AAV-m-SNCB-shRNA
Ready-to-use AAV expressing shRNA for silencing of Mouse Sncb (synuclein, beta). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
AI838531; betaSYN
Description (Vector)
Non-amyloid component of senile plaques found in Alzheimer disease. Could act as a regulator of SNCA aggregation process. Protects neurons from staurosporine and 6-hydroxy dopamine (6OHDA)-stimulated caspase activation in a p53/TP53-dependent manner. Contributes to restore the SNCA anti-apoptotic function abolished by 6OHDA. Not found in the Lewy bodies associated with Parkinson disease.
Gene ID
104069
Gene Name (Vector)
synuclein, beta
Gene Symbol
Sncb
ORF Size (aa)
402
RefSeq ID
NM_033610
RefSeq Synonyms
NM_033610, BC019409,
Species
mouse
UniGene ID
Mm.200843
About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.