mouse SMAD7 shRNA silencing AAV
This is an AAV expressing shRNA for silencing of Mouse Smad7.
shAAV-272605
AAV-m-SMAD7-shRNA
Ready-to-use AAV expressing shRNA for silencing of Mouse Smad7 (SMAD family member 7). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
Madh7
Description (Vector)
Antagonist of signaling by TGF-beta (transforming growth factor) type 1 receptor superfamily members; has been shown to inhibit TGF-beta (Transforming growth factor) and activin signaling by associating with their receptors thus preventing SMAD2 access. Functions as an adapter to recruit SMURF2 to the TGF-beta receptor complex. Also acts by recruiting the PPP1R15A-PP1 complex to TGFBR1, which promotes its dephosphorylation. Positively regulates PDPK1 kinase activity by stimulating its dissociation from the 14-3-3 protein YWHAQ which acts as a negative regulator (By similarity).
Gene ID
17131
Gene Name (Vector)
SMAD family member 7
Gene Symbol
Smad7
ORF Size (aa)
1281
ORF Size (bp)
1281 bp
RefSeq ID
NM_001042660
RefSeq Synonyms
NM_001042660, BC137638,
Species
mouse
UniGene ID
Mm.34407
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About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.