mouse SLC7A5 shRNA silencing AAV
This is an AAV expressing shRNA for silencing of Mouse Slc7a5.
shAAV-272514
AAV-m-SLC7A5-shRNA
Ready-to-use AAV expressing shRNA for silencing of Mouse Slc7a5 (solute carrier family 7 (cationic amino acid transporter, y+ system), member 5). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
4F2LC; D0H16S474E; LAT1; TA1
Description (Vector)
Sodium-independent, high-affinity transport of large neutral amino acids such as phenylalanine, tyrosine, leucine, arginine and tryptophan, when associated with SLC3A2/4F2hc. Involved in cellular amino acid uptake. Acts as an amino acid exchanger. Involved in the transport of L-DOPA across the blood-brain barrier, and that of thyroid hormones triiodothyronine (T3) and thyroxine (T4) across the cell membrane in tissues such as placenta. Plays a role in neuronal cell proliferation (neurogenesis) in brain. Involved in the uptake of methylmercury (MeHg) when administered as the L-cysteine or D,L-homocysteine complexes, and hence plays a role in metal ion homeostasis and toxicity. Involved in the cellular activity of small molecular weight nitrosothiols, via the stereoselective transport of L-nitrosocysteine (L-CNSO) across the transmembrane. May play an important role in high-grade gliomas. Mediates blood-to-retina L-leucine transport across the inner blood-retinal barrier which in turn may play a key role in maintaining large neutral amino acids as well as neurotransmitters in the neural retina. Acts as the major transporter of tyrosine in fibroblasts.
Gene ID
20539
Gene Name (Vector)
solute carrier family 7 (cationic amino acid transporter, y+ system), member 5
Gene Symbol
Slc7a5
ORF Size (aa)
1539
ORF Size (bp)
1539 bp
RefSeq ID
NM_011404
RefSeq Synonyms
NM_011404, BC026131,
Species
mouse
UniGene ID
Mm.27943
About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.