mouse SIGMAR1 shRNA silencing AAV

Name
AAV-m-SIGMAR1-shRNA

Cat No
shAAV-271989

Availability
4-5 weeks

This is an AAV expressing shRNA for silencing of Mouse Sigmar1.

shAAV-271989

AAV-m-SIGMAR1-shRNA

Ready-to-use AAV expressing shRNA for silencing of Mouse Sigmar1 (sigma non-opioid intracellular receptor 1). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype

Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids

AAV ITR

AAV2

Promoter

U6 ()

Reporter

eGFP (default), optional CFP, YFP, RFP, mCherry

shRNA Knockdown (%)

Storage Buffer

PBS/5% Glycerol

Viral Backbone

Recombinant AAV

Gene Reference Data

Alternate Names

Oprs1; Sig1R; sigma1R

Description (Vector)

Functions in lipid transport from the endoplasmic reticulum and is involved in a wide array of cellular functions probably through regulation of the biogenesis of lipid microdomains at the plasma membrane. Involved in the regulation of different receptors it plays a role in BDNF signaling and EGF signaling. Also regulates ion channels like the potassium channel and could modulate neurotransmitter release. Plays a role in calcium signaling through modulation together with ANK2 of the ITP3R-dependent calcium efflux at the endoplasmic reticulum. Plays a role in several other cell functions including proliferation, survival and death. Originally identified for its ability to bind various psychoactive drugs it is involved in learning processes, memory and mood alteration.

Gene ID

18391

Gene Name (Vector)

sigma non-opioid intracellular receptor 1

Gene Symbol

Sigmar1

ORF Size (aa)

672

ORF Size (bp)

672 bp

RefSeq ID

NM_011014

RefSeq Synonyms

NM_011014, NM_001286605, NM_001286551, NM_001286542, NM_001286541, NM_001286540, NM_001286539, NM_001286538, BC019930, BC002000,

Species

mouse

UniGene ID

Mm.425181

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.