mouse SEMA7A shRNA silencing AAV

Name 
AAV-m-SEMA7A-shRNA
Cat No 
shAAV-271603
Availability
4-5 weeks
Categories
AAV, shRNA-Silencing

This is an AAV expressing shRNA for silencing of Mouse Sema7a.

shAAV-271603
AAV-m-SEMA7A-shRNA

Ready-to-use AAV expressing shRNA for silencing of Mouse Sema7a (sema domain, immunoglobulin domain (Ig), and GPI membrane anchor, (semaphorin) 7A). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype
Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
AAV ITR
AAV2
Promoter
U6 ()
Reporter
eGFP (default), optional CFP, YFP, RFP, mCherry
shRNA Knockdown (%)
90
Storage Buffer
PBS/5% Glycerol
Viral Backbone
Recombinant AAV

Gene Reference Data

Alternate Names
2900057C09Rik; CDw108; H-Sema-L; M-Sema-L; Semal
Description (Vector)
Plays an important role in integrin-mediated signaling and functions both in regulating cell migration and immune responses. Promotes formation of focal adhesion complexes, activation of the protein kinase PTK2/FAK1 and subsequent phosphorylation of MAPK1 and MAPK3. Promotes production of proinflammatory cytokines by monocytes and macrophages. Plays an important role in modulating inflammation and T-cell-mediated immune responses. Promotes axon growth in the embryonic olfactory bulb. Promotes attachment, spreading and dendrite outgrowth in melanocytes.
Gene ID
20361
Gene Name (Vector)
sema domain, immunoglobulin domain (Ig), and GPI membrane anchor, (semaphorin) 7A
Gene Symbol
Sema7a
ORF Size (aa)
1995
ORF Size (bp)
1995 bp
RefSeq ID
NM_011352
RefSeq Synonyms
NM_011352, BC057875,
Species
mouse
UniGene ID
Mm.335187

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.