mouse SEMA3E shRNA silencing AAV

Name
AAV-m-SEMA3E-shRNA

Cat No
shAAV-271586

Availability
6-8 weeks

This is an AAV expressing shRNA for silencing of Mouse Sema3e.

shAAV-271586

AAV-m-SEMA3E-shRNA

Ready-to-use AAV expressing shRNA for silencing of Mouse Sema3e (sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3E). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype

Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids

AAV ITR

AAV2

Promoter

U6 ()

Reporter

eGFP (default), optional CFP, YFP, RFP, mCherry

Storage Buffer

PBS/5% Glycerol

Viral Backbone

Recombinant AAV

Gene Reference Data

Alternate Names

6430702L12; AA408817; mKIAA0331; Semah

Description (Vector)

Plays an important role in signaling via the cell surface receptor PLXND1. Mediates reorganization of the actin cytoskeleton, leading to the retraction of cell projections. Promotes focal adhesion disassembly and inhibits adhesion of endothelial cells to the extracellular matrix. Regulates angiogenesis, both during embryogenesis and after birth. Can down-regulate sprouting angiogenesis. Required for normal vascular patterning during embryogenesis. Plays an important role in ensuring the specificity of synapse formation (By similarity).

Gene ID

20349

Gene Name (Vector)

sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3E

Gene Symbol

Sema3e

ORF Size (aa)

2328

ORF Size (bp)

2328 bp

RefSeq ID

NM_011348

RefSeq Synonyms

NM_011348, BC057956,

Species

mouse

UniGene ID

Mm.134093

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.