human HDAC3 Over-expression AAV

Name 
AAV-h-HDAC3
Cat No 
AAV-210888
Availability
4-5 weeks
Categories
AAV, Over-Expression

This is an AAV expressing Human HDAC3.

AAV-210888
AAV-h-HDAC3

Ready-to-use AAV expressing Human HDAC3 (histone deacetylase 3). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype
Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
AAV ITR
AAV2
Promoter
CMV (default), or choose from 30 different ubiquitous or cell specific promoter
Reporter
none, optional GFP, CFP, YFP, RFP or mCherry
Storage Buffer
PBS/5% Glycerol
Viral Backbone
Recombinant AAV

Gene Reference Data

Alternate Names
HD3; histone deacetylase 3; RPD3; RPD3-2; SMAP45
Description (eCommerce)
Histone deacetylase 3 (HDAC3) is a class I histone deacetylase that catalyzes the removal of the acetyl group on lysine residues of the N-terminus of the core histones H2A, H2B, H3, and H4. HDAC3 is found in multi-protein complexes and its activity depends on its interaction with the co-repressors SMRT and N-CoR.
Description (Vector)
Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. The protein encoded by this gene belongs to the histone deacetylase/acuc/apha family. It has histone deacetylase activity and represses transcription when tethered to a promoter. It may participate in the regulation of transcription through its binding with the zinc-finger transcription factor YY1. This protein can also down-regulate p53 function and thus modulate cell growth and apoptosis. This gene is regarded as a potential tumor suppressor gene.
Gene ID
8841
Gene Name (eCommerce)
histone deacetylase 3
Gene Name (Vector)
histone deacetylase 3
Gene Symbol
HDAC3
HGNC ID
HGNC:4854
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
1287
ORF Size (bp)
1287 bp
Protein Name (eCommerce)
Histone deacetylase 3
RefSeq ID
NM_003883
RefSeq Synonyms
NM_003883, BC000614,
Research Areas
Apoptosis,Cancer,Cell Cycle,Chromatin Remodeling,Histone Modification,Host-Virus Interactions,JNK Signaling,Metabolism/Metabolic Process,Neurobiology,Neurodevelopment,NGF Signaling,Notch Signaling,Signal Transduction,TGF-beta Signaling,Transcription Factor/Regulator,Viral Carcinogenesis
Research Areas (Faceted)
cancer,signal_transduction,cell_biology,cell_cycle,transcription_translation,genetics,infectious_disease,signal_transduction,metabolism,neurobiology,developmental_biology,developmental_biology,signal_transduction,immunology,genetics,transcription_translation,cancer,infectious_disease
Species
human
Target Sentence
Histone deacetylase 3 (HDAC3) is a class I histone deacetylase that catalyzes the removal of the acetyl group on lysine residues of the N-terminus of the core histones H2A, H2B, H3, and H4. HDAC3 is found in multi-protein complexes and its activity depends on its interaction with the co-repressors SMRT and N-CoR.
UniGene ID
Hs.519632
UniProt ID (eCommerce)
O15379

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.