human HARS Over-expression AAV

Name 
AAV-h-HARS
Cat No 
AAV-210785
Availability
4-5 weeks
Categories
AAV, Over-Expression

This is an AAV expressing Human HARS.

AAV-210785
AAV-h-HARS

Ready-to-use AAV expressing Human HARS (histidyl-tRNA synthetase). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype
Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
AAV ITR
AAV2
Promoter
CMV (default), or choose from 30 different ubiquitous or cell specific promoter
Reporter
none, optional GFP, CFP, YFP, RFP or mCherry
Storage Buffer
PBS/5% Glycerol
Viral Backbone
Recombinant AAV

Gene Reference Data

Alternate Names
CMT2W; HRS; USH3B
Description (Vector)
Aminoacyl-tRNA synthetases are a class of enzymes that charge tRNAs with their cognate amino acids. The protein encoded by this gene is a cytoplasmic enzyme which belongs to the class II family of aminoacyl-tRNA synthetases. The enzyme is responsible for the synthesis of histidyl-transfer RNA, which is essential for the incorporation of histidine into proteins. The gene is located in a head-to-head orientation with HARSL on chromosome five, where the homologous genes share a bidirectional promoter. The gene product is a frequent target of autoantibodies in the human autoimmune disease polymyositis/dermatomyositis. Several transcript variants encoding different isoforms have been found for this gene.
Gene ID
3035
Gene Name (Vector)
histidyl-tRNA synthetase
Gene Symbol
HARS
HGNC ID
HGNC:4816
ORF Size (aa)
1530
ORF Size (bp)
1530 bp
RefSeq ID
NM_002109
RefSeq Synonyms
NM_002109, NM_001289094, NM_001289093, NM_001289092, NM_001258042, NM_001258041, NM_001258040, BC080514, BC011807,
Species
human
UniGene ID
Hs.528050

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.