mouse PVRL3 shRNA silencing AAV
This is an AAV expressing shRNA for silencing of Mouse Nectin3.
shAAV-269877
AAV-m-PVRL3-shRNA
Ready-to-use AAV expressing shRNA for silencing of Mouse Nectin3 (nectin cell adhesion molecule 3). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
2610301B19Rik; 3000002N23Rik; 4921513D19Rik; AA407785; AU016832; AW538082; CD113; Pvrl3
Description (Vector)
Plays a role in cell-cell adhesion through heterophilic trans-interactions with nectin-like proteins or nectins, such as trans-interaction with PVRL2/nectin-2 at Sertoli-spermatid junctions. Trans-interaction with PVR induces activation of CDC42 and RAC small G proteins through common signaling molecules such as SRC and RAP1. Also involved in the formation of cell-cell junctions, including adherens junctions and synapses. Induces endocytosis-mediated down-regulation of PVR from the cell surface, resulting in reduction of cell movement and proliferation. Plays a role in the morphology of the ciliary body.
Gene ID
58998
Gene Name (Vector)
nectin cell adhesion molecule 3
Gene Symbol
Nectin3
ORF Size (aa)
1317
ORF Size (bp)
1317 bp
RefSeq ID
NM_021495
RefSeq Synonyms
NM_021497, NM_021496, NM_021495, BC132187, BC125588,
Species
mouse
UniGene ID
Mm.440435
About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.