mouse PVR shRNA silencing AAV
This is an AAV expressing shRNA for silencing of Mouse Pvr.
shAAV-269869
AAV-m-PVR-shRNA
Ready-to-use AAV expressing shRNA for silencing of Mouse Pvr (poliovirus receptor). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
3830421F03Rik; CD155; D7Ertd458e; HVED; mE4; necl-5; PVS; Taa1; Tage4
Description (Vector)
Mediates NK cell adhesion and triggers NK cell effector functions. Binds two different NK cell receptors: CD96 and CD226. These interactions accumulates at the cell-cell contact site, leading to the formation of a mature immunological synapse between NK cell and target cell. This may trigger adhesion and secretion of lytic granules and IFN-gamma and activate cytoxicity of activated NK cells. May also promote NK cell-target cell modular exchange, and PVR transfer to the NK cell. This transfer is more important in some tumor cells expressing a lot of PVR, and may trigger fratricide NK cell activation, providing tumors with a mechanism of immunoevasion. Plays a role in mediating tumor cell invasion and migration. Serves as a receptor for poliovirus attachment to target cells. May play a role in axonal transport of poliovirus, by targeting virion-PVR-containing endocytic vesicles to the microtubular network through interaction with DYNLT1. This interaction would drive the virus-containing vesicle to the axonal retrograde transport.
Gene ID
52118
Gene Name (Vector)
poliovirus receptor
Gene Symbol
Pvr
ORF Size (aa)
1227
ORF Size (bp)
1227 bp
RefSeq ID
NM_027514
RefSeq Synonyms
NM_027514, BC138220, BC138219, BC032283, BC013673,
Species
mouse
UniGene ID
Mm.227506
About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.