mouse PRKAG3 shRNA silencing AAV
This is an AAV expressing shRNA for silencing of Mouse Prkag3.
shAAV-269367
AAV-m-PRKAG3-shRNA
Ready-to-use AAV expressing shRNA for silencing of Mouse Prkag3 (protein kinase, AMP-activated, gamma 3 non-catatlytic subunit). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
Amkg3; Ampkg3; AMPKg3L; AMPKg3S
Description (Vector)
AMP/ATP-binding subunit of AMP-activated protein kinase (AMPK), an energy sensor protein kinase that plays a key role in regulating cellular energy metabolism. In response to reduction of intracellular ATP levels, AMPK activates energy-producing pathways and inhibits energy-consuming processes: inhibits protein, carbohydrate and lipid biosynthesis, as well as cell growth and proliferation. AMPK acts via direct phosphorylation of metabolic enzymes, and by longer-term effects via phosphorylation of transcription regulators. Also acts as a regulator of cellular polarity by remodeling the actin cytoskeleton; probably by indirectly activating myosin. Gamma non-catalytic subunit mediates binding to AMP, ADP and ATP, leading to activate or inhibit AMPK: AMP-binding results in allosteric activation of alpha catalytic subunit (PRKAA1 or PRKAA2) both by inducing phosphorylation and preventing dephosphorylation of catalytic subunits. ADP also stimulates phosphorylation, without stimulating already phosphorylated catalytic subunit. ATP promotes dephosphorylation of catalytic subunit, rendering the AMPK enzyme inactive.
Gene ID
241113
Gene Name (Vector)
protein kinase, AMP-activated, gamma 3 non-catatlytic subunit
Gene Symbol
Prkag3
ORF Size (aa)
1395
ORF Size (bp)
1395 bp
RefSeq ID
NM_153744
RefSeq Synonyms
NM_153744, BC116777, BC116749,
Species
mouse
UniGene ID
Mm.166501
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About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.