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mouse PHLPPL shRNA silencing AAV

Name 
AAV-m-PHLPPL-shRNA
Cat No 
shAAV-268563
Availability
6-8 weeks
Categories
AAV, shRNA-Silencing

This is an AAV expressing shRNA for silencing of Mouse Phlpp2.

shAAV-268563
AAV-m-PHLPPL-shRNA

Ready-to-use AAV expressing shRNA for silencing of Mouse Phlpp2 (PH domain and leucine rich repeat protein phosphatase 2). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype
Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
AAV ITR
AAV2
Promoter
U6 ()
Reporter
eGFP (default), optional CFP, YFP, RFP, mCherry
Storage Buffer
PBS/5% Glycerol
Viral Backbone
Recombinant AAV

Gene Reference Data

Alternate Names
AI481772; C130044A18Rik; Phlppl
Description (Vector)
Protein phosphatase that mediates dephosphorylation of 'Ser-473' of AKT1, 'Ser-660' of PRKCB isoform beta-II and 'Ser-657' of PRKCA. AKT1 regulates the balance between cell survival and apoptosis through a cascade that primarily alters the function of transcription factors that regulate pro- and antiapoptotic genes. Dephosphorylation of 'Ser-473' of AKT1 triggers apoptosis and decreases cell proliferation. Also controls the phosphorylation of AKT3. Dephosphorylation of PRKCA and PRKCB leads to their destabilization and degradation. Inhibits cancer cell proliferation and may act as a tumor suppressor.
Gene ID
244650
Gene Name (Vector)
PH domain and leucine rich repeat protein phosphatase 2
Gene Symbol
Phlpp2
ORF Size (aa)
3963
ORF Size (bp)
3963 bp
RefSeq ID
NM_001122594
RefSeq Synonyms
NM_001122594, BC117962, BC117961,
Species
mouse
UniGene ID
Mm.23494

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.