mouse PAK4 shRNA silencing AAV
This is an AAV expressing shRNA for silencing of Mouse Pak4.
shAAV-268018
AAV-m-PAK4-shRNA
Ready-to-use AAV expressing shRNA for silencing of Mouse Pak4 (p21 protein (Cdc42/Rac)-activated kinase 4). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
5730488L07Rik; AW555722; mKIAA1142
Description (Vector)
Serine/threonine protein kinase that plays a role in a variety of different signaling pathways including cytoskeleton regulation, cell migration, growth, proliferation or cell survival. Activation by various effectors including growth factor receptors or active CDC42 and RAC1 results in a conformational change and a subsequent autophosphorylation on several serine and/or threonine residues. Phosphorylates and inactivates the protein phosphatase SSH1, leading to increased inhibitory phosphorylation of the actin binding/depolymerizing factor cofilin. Decreased cofilin activity may lead to stabilization of actin filaments. Phosphorylates LIMK1, a kinase that also inhibits the activity of cofilin. Phosphorylates integrin beta5/ITGB5 and thus regulates cell motility. Phosphorylates ARHGEF2 and activates the downstream target RHOA that plays a role in the regulation of assembly of focal adhesions and actin stress fibers. Stimulates cell survival by phosphorylating the BCL2 antagonist of cell death BAD. Alternatively, inhibits apoptosis by preventing caspase-8 binding to death domain receptors in a kinase independent manner. Plays a role in cell-cycle progression by controlling levels of the cell-cycle regulatory protein CDKN1A and by phosphorylating RAN.
Gene ID
70584
Gene Name (Vector)
p21 protein (Cdc42/Rac)-activated kinase 4
Gene Symbol
Pak4
ORF Size (aa)
1782
ORF Size (bp)
1782 bp
RefSeq ID
NM_027470
RefSeq Synonyms
NM_027470, BC048238,
Species
mouse
UniGene ID
Mm.21876
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About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.