mouse OPA1 shRNA silencing AAV

Name
AAV-m-OPA1-shRNA

Cat No
shAAV-267654

Availability
Immediate

This is an AAV expressing shRNA for silencing of Mouse Opa1.

shAAV-267654

AAV-m-OPA1-shRNA

Ready-to-use AAV expressing shRNA for silencing of Mouse Opa1 (optic atrophy 1). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype

Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids

AAV ITR

AAV2

Promoter

U6 ()

Reporter

eGFP (default), optional CFP, YFP, RFP, mCherry

shRNA Knockdown (%)

Storage Buffer

PBS/5% Glycerol

Viral Backbone

Recombinant AAV

Gene Reference Data

Alternate Names

1200011N24Rik; AI225888; AI847218; lilr3; mKIAA0567

Description (Vector)

Dynamin-related GTPase required for mitochondrial fusion and regulation of apoptosis. May form a diffusion barrier for proteins stored in mitochondrial cristae. Proteolytic processing in response to intrinsic apoptotic signals may lead to disassembly of OPA1 oligomers and release of the caspase activator cytochrome C (CYCS) into the mitochondrial intermembrane space|Function: Dynamin-like 120 kDa protein, form S1: Inactive form produced by cleavage at S1 position by OMA1 following stress conditions that induce loss of mitochondrial membrane potential, leading to negative regulation of mitochondrial fusion.

Gene ID

74143

Gene Name (Vector)

optic atrophy 1

Gene Symbol

Opa1

ORF Size (aa)

2883

ORF Size (bp)

2883 bp

RefSeq ID

NM_133752

RefSeq Synonyms

NM_133752, NM_001199177, BC145959, BC138665,

Species

mouse

UniGene ID

Mm.274285

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.