human GPS1 Over-expression AAV

Name 
AAV-h-GPS1
Cat No 
AAV-210439
Availability
4-5 weeks
Categories
AAV, Over-Expression

This is an AAV expressing Human GPS1.

AAV-210439
AAV-h-GPS1

Ready-to-use AAV expressing Human GPS1 (G protein pathway suppressor 1). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype
Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
AAV ITR
AAV2
Promoter
CMV (default), or choose from 30 different ubiquitous or cell specific promoter
Reporter
none, optional GFP, CFP, YFP, RFP or mCherry
Storage Buffer
PBS/5% Glycerol
Viral Backbone
Recombinant AAV

Gene Reference Data

Alternate Names
COP9 signalosome complex subunit 1; COPS1; CSN1; G protein pathway suppressor 1; GPS-1; JAB1-containing signalosome subunit 1; Protein MFH; SGN1; Signalosome subunit 1
Description (eCommerce)
CSN1 is one of eight subunits (CSN1 to 8) of the highly conserved COP9 signalsome (CSN) complex originally identified as a regulator of light-mediated development in Arabidopsis. Characterization of CSN from yeast to mammals reveals a function as a modulator of signal transduction pathways involved in a variety of cellular and developmental processes. One of the major functions of the CSN is the regulation of protein degradation via intersection with the ubiquitin-proteasome pathway and regulation of E3-ubiquitin ligases.
Description (Vector)
GPS1 is known to suppress G-protein and mitogen-activated signal transduction in mammalian cells. The encoded protein shares significant similarity with Arabidopsis FUS6, which is a regulator of light-mediated signal transduction in plant cells. Two alternatively spliced transcript variants encoding different isoforms have been found for this gene.
Gene ID
2873
Gene Name (eCommerce)
G protein pathway suppressor 1
Gene Name (Vector)
G protein pathway suppressor 1
Gene Symbol
GPS1
HGNC ID
HGNC:4549
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
1476
ORF Size (bp)
1476 bp
Protein Name (eCommerce)
COP9 signalosome complex subunit 1
RefSeq ID
NM_004127
RefSeq Synonyms
NM_212492, NM_004127, NM_001330541, NM_001330539, NM_001321093, NM_001321092, NM_001321091, NM_001321090, NM_001321089, BC064503, BC000155,
Research Areas
Cell Cycle
Research Areas (Faceted)
cell_biology,cell_cycle,genetics
Species
human
Target Sentence
CSN1 is one of eight subunits (CSN1 to 8) of the highly conserved COP9 signalsome (CSN) complex originally identified as a regulator of light-mediated development in Arabidopsis. Characterization of CSN from yeast to mammals reveals a function as a modulator of signal transduction pathways involved in a variety of cellular and developmental processes. One of the major functions of the CSN is the regulation of protein degradation via intersection with the ubiquitin-proteasome pathway and regulation of E3-ubiquitin ligases.
UniGene ID
Hs.268530
UniProt ID (eCommerce)
Q13098

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.