mouse NR1H4 shRNA silencing AAV

Name 
AAV-m-NR1H4-shRNA
Cat No 
shAAV-266036
Availability
4-5 weeks
Categories
AAV, shRNA-Silencing

This is an AAV expressing shRNA for silencing of Mouse Nr1h4.

shAAV-266036
AAV-m-NR1H4-shRNA

Ready-to-use AAV expressing shRNA for silencing of Mouse Nr1h4 (nuclear receptor subfamily 1, group H, member 4). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype
Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
AAV ITR
AAV2
Promoter
U6 ()
Reporter
eGFP (default), optional CFP, YFP, RFP, mCherry
shRNA Knockdown (%)
80
Storage Buffer
PBS/5% Glycerol
Viral Backbone
Recombinant AAV

Gene Reference Data

Alternate Names
AI957360; Fxr; HRR1; RIP14; Rxrip14
Description (Vector)
Ligand-activated transcription factor. Receptor for bile acids such as chenodeoxycholic acid, lithocholic acid and deoxycholic acid. Represses the transcription of the cholesterol 7-alpha-hydroxylase gene (CYP7A1) through the induction of NR0B2 or FGF19 expression, via two distinct mechanisms. Activates the intestinal bile acid-binding protein (IBABP). Activates the transcription of bile salt export pump ABCB11 by directly recruiting histone methyltransferase CARM1 to this locus.
Gene ID
20186
Gene Name (Vector)
nuclear receptor subfamily 1, group H, member 4
Gene Symbol
Nr1h4
ORF Size (aa)
1455
ORF Size (bp)
1455 bp
RefSeq ID
NM_009108
RefSeq Synonyms
NM_009108, NM_001163700, NM_001163504, BC015261,
Species
mouse
UniGene ID
Mm.3095

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.