mouse NLRP3 shRNA silencing AAV
This is an AAV expressing shRNA for silencing of Mouse Nlrp3.
shAAV-265850
AAV-m-NLRP3-shRNA
Ready-to-use AAV expressing shRNA for silencing of Mouse Nlrp3 (NLR family, pyrin domain containing 3). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
AGTAVPRL; AII/AVP; Cias1; FCAS; FCU; Mmig1; MWS; NALP3; Pypaf1
Description (Vector)
NLRP3 may function as an inducer of apoptosis. Interacts selectively with ASC and this complex may function as an upstream activator of NF-kappa-B signaling. Inhibits TNF-alpha induced activation and nuclear translocation of RELA/NF-KB p65. Also inhibits transcriptional activity of RELA. Activates caspase-1 in response to a number of triggers including bacterial or viral infection which leads to processing and release of IL1B and IL18.
Gene ID
216799
Gene Name (Vector)
NLR family, pyrin domain containing 3
Gene Symbol
Nlrp3
ORF Size (aa)
2490
ORF Size (bp)
2490 bp
RefSeq ID
NM_145827
RefSeq Synonyms
NM_145827, BC116175, BC116174,
Species
mouse
UniGene ID
Mm.54174
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About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.