mouse NLGN2 shRNA silencing AAV
This is an AAV expressing shRNA for silencing of Mouse Nlgn2.
shAAV-265834
AAV-m-NLGN2-shRNA
Ready-to-use AAV expressing shRNA for silencing of Mouse Nlgn2 (neuroligin 2). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
NL2
Description (Vector)
Transmembrane scaffolding protein involved in cell-cell interactions via its interactions with neurexin family members. Mediates cell-cell interactions both in neurons and in other types of cells, such as Langerhans beta cells. Plays a role in synapse function and synaptic signal transmission, especially via gamma-aminobutyric acid receptors (GABA(A) receptors). Functions by recruiting and clustering synaptic proteins. Promotes clustering of postsynaptic GABRG2 and GPHN. Modulates signaling by inhibitory synapses, and thereby plays a role in controlling the ratio of signaling by excitatory and inhibitory synapses and information processing. Required for normal signal amplitude from inhibitory synapses, but is not essential for normal signal frequency. May promote the initial formation of synapses, but is not essential for this. In vitro, triggers the de novo formation of presynaptic structures. Mediates cell-cell interactions between Langerhans beta cells and modulates insulin secretion (By similarity).
Gene ID
216856
Gene Name (Vector)
neuroligin 2
Gene Symbol
Nlgn2
ORF Size (aa)
2508
ORF Size (bp)
2508 bp
RefSeq ID
NM_198862
RefSeq Synonyms
NM_198862, BC156963, BC156101,
Species
mouse
UniGene ID
Mm.151293
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About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.