mouse NHLRC1 shRNA silencing AAV

Name 
AAV-m-NHLRC1-shRNA
Cat No 
shAAV-265755
Availability
6-8 weeks
Categories
AAV, shRNA-Silencing

This is an AAV expressing shRNA for silencing of Mouse Nhlrc1.

shAAV-265755
AAV-m-NHLRC1-shRNA

Ready-to-use AAV expressing shRNA for silencing of Mouse Nhlrc1 (NHL repeat containing 1). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype
Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
AAV ITR
AAV2
Promoter
U6 ()
Reporter
eGFP (default), optional CFP, YFP, RFP, mCherry
Storage Buffer
PBS/5% Glycerol
Viral Backbone
Recombinant AAV

Gene Reference Data

Alternate Names
AI505271; B230309E09Rik; EPM2B
Description (Vector)
E3 ubiquitin-protein ligase which in complex with EPM2A/laforin and HSP70 suppresses the cellular toxicity of misfolded proteins by promoting their degradation through the ubiquitin-proteasome system (UPS). Ubiquitinates PPP1R3C/PTG in a laforin-dependent manner, and targets it for proteasome-dependent degradation and this degradation decreases glycogen accumulation. Polyubiquitinates EPM2A/laforin and ubiquitinates AGL and targets them for proteasome-dependent degradation.
Gene ID
105193
Gene Name (Vector)
NHL repeat containing 1
Gene Symbol
Nhlrc1
ORF Size (aa)
1206
ORF Size (bp)
1206 bp
RefSeq ID
NM_175340
RefSeq Synonyms
NM_175340, BC118952, BC118951,
Species
mouse
UniGene ID
Mm.25593

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.