mouse NCOA1 shRNA silencing AAV

Name
AAV-m-NCOA1-shRNA

Cat No
shAAV-265516

Availability
4-5 weeks

This is an AAV expressing shRNA for silencing of Mouse Ncoa1.

shAAV-265516

AAV-m-NCOA1-shRNA

Ready-to-use AAV expressing shRNA for silencing of Mouse Ncoa1 (nuclear receptor coactivator 1). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype

Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids

AAV ITR

AAV2

Promoter

U6 ()

Reporter

eGFP (default), optional CFP, YFP, RFP, mCherry

shRNA Knockdown (%)

Storage Buffer

PBS/5% Glycerol

Viral Backbone

Recombinant AAV

Gene Reference Data

Alternate Names

bHLHe74; KAT13A; mNRC-1; NCoA-1; NRC-1; SRC-1; SRC-a; SRC1

Description (Vector)

Nuclear receptor coactivator that directly binds nuclear receptors and stimulates the transcriptional activities in a hormone-dependent fashion. Involved in the coactivation of different nuclear receptors, such as for steroids (PGR, GR and ER), retinoids (RXRs), thyroid hormone (TRs) and prostanoids (PPARs). Also involved in coactivation mediated by STAT3, STAT5A, STAT5B and STAT6 transcription factors. Displays histone acetyltransferase activity toward H3 and H4; the relevance of such activity remains however unclear. Plays a central role in creating multisubunit coactivator complexes that act via remodeling of chromatin, and possibly acts by participating in both chromatin remodeling and recruitment of general transcription factors. Required with NCOA2 to control energy balance between white and brown adipose tissues. Required for mediating steroid hormone response. Isoform 2 has a higher thyroid hormone-dependent transactivation activity than isoform 1 and isoform 3.

Gene ID

17977

Gene Name (Vector)

nuclear receptor coactivator 1

Gene Symbol

Ncoa1

ORF Size (aa)

4218

ORF Size (bp)

4218 bp

RefSeq ID

NM_010881

RefSeq Synonyms

NM_010881, BC080866, BC068177,

Species

mouse

UniGene ID

Mm.392997

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.