mouse MKRN1 shRNA silencing AAV
This is an AAV expressing shRNA for silencing of Mouse Mkrn1.
shAAV-264676
AAV-m-MKRN1-shRNA
Ready-to-use AAV expressing shRNA for silencing of Mouse Mkrn1 (makorin, ring finger protein, 1). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
RFP
Description (Vector)
E3 ubiquitin ligase catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins. These substrates include FILIP1, p53/TP53, CDKN1A and TERT. Keeps cells alive by suppressing p53/TP53 under normal conditions, but stimulates apoptosis by repressing CDKN1A under stress conditions. Acts as a negative regulator of telomerase. Has negative and positive effects on RNA polymerase II-dependent transcription.
Gene ID
54484
Gene Name (Vector)
makorin, ring finger protein, 1
Gene Symbol
Mkrn1
ORF Size (aa)
990
ORF Size (bp)
990 bp
RefSeq ID
NM_018810
RefSeq Synonyms
NM_018810, NM_001311109, BC003329,
Species
mouse
UniGene ID
Mm.270484
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About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.