mouse MDM4 shRNA silencing AAV
This is an AAV expressing shRNA for silencing of Mouse Mdm4.
shAAV-264423
AAV-m-MDM4-shRNA
Ready-to-use AAV expressing shRNA for silencing of Mouse Mdm4 (transformed mouse 3T3 cell double minute 4). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
4933417N07Rik; AA414968; AL023055; AU018793; AU021806; C85810; Mdmx
Description (Vector)
Inhibits p53/TP53- and TP73/p73-mediated cell cycle arrest and apoptosis by binding its transcriptional activation domain. Inhibits degradation of MDM2. Can reverse MDM2-targeted degradation of TP53 while maintaining suppression of TP53 transactivation and apoptotic functions.
Gene ID
17248
Gene Name (Vector)
transformed mouse 3T3 cell double minute 4
Gene Symbol
Mdm4
ORF Size (aa)
1473
ORF Size (bp)
1473 bp
RefSeq ID
NM_008575
RefSeq Synonyms
NM_008575, NM_001302804, NM_001302803, NM_001302802, NM_001302801, BC003750,
Species
mouse
UniGene ID
Mm.476028
About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.