mouse MCM3 shRNA silencing AAV

Name
AAV-m-MCM3-shRNA

Cat No
shAAV-264373

Availability
4-5 weeks

This is an AAV expressing shRNA for silencing of Mouse Mcm3.

shAAV-264373

AAV-m-MCM3-shRNA

Ready-to-use AAV expressing shRNA for silencing of Mouse Mcm3 (minichromosome maintenance complex component 3). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype

Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids

AAV ITR

AAV2

Promoter

U6 ()

Reporter

eGFP (default), optional CFP, YFP, RFP, mCherry

shRNA Knockdown (%)

Storage Buffer

PBS/5% Glycerol

Viral Backbone

Recombinant AAV

Gene Reference Data

Alternate Names

AL033361; C80350; Mcmd; P1; p1.m

Description (Vector)

Acts as component of the MCM2-7 complex (MCM complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity. Required for DNA replication and cell proliferation.

Gene ID

17215

Gene Name (Vector)

minichromosome maintenance complex component 3

Gene Symbol

Mcm3

ORF Size (aa)

2439

ORF Size (bp)

2439 bp

RefSeq ID

NM_008563

RefSeq Synonyms

NM_008563, BC031700,

Species

mouse

UniGene ID

Mm.4502

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.