mouse MAPK13 shRNA silencing AAV
This is an AAV expressing shRNA for silencing of Mouse Mapk13.
shAAV-264214
AAV-m-MAPK13-shRNA
Ready-to-use AAV expressing shRNA for silencing of Mouse Mapk13 (mitogen-activated protein kinase 13). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
SAPK4; Serk4
Description (Vector)
Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. MAPK13 is one of the four p38 MAPKs which play an important role in the cascades of cellular responses evoked by extracellular stimuli such as proinflammatory cytokines or physical stress leading to direct activation of transcription factors such as ELK1 and ATF2. Accordingly, p38 MAPKs phosphorylate a broad range of proteins and it has been estimated that they may have approximately 200 to 300 substrates each. MAPK13 is one of the less studied p38 MAPK isoforms. Some of the targets are downstream kinases such as MAPKAPK2, which are activated through phosphorylation and further phosphorylate additional targets. Plays a role in the regulation of protein translation by phosphorylating and inactivating EEF2K. Involved in cytoskeletal remodeling through phosphorylation of MAPT and STMN1. Mediates UV irradiation induced up-regulation of the gene expression of CXCL14. Plays an important role in the regulation of epidermal keratinocyte differentiation, apoptosis and skin tumor development. Phosphorylates the transcriptional activator MYB in response to stress which leads to rapid MYB degradation via a proteasome-dependent pathway. MAPK13 also phosphorylates and down-regulates PRKD1 during regulation of insulin secretion in pancreatic beta cells.
Gene ID
26415
Gene Name (Vector)
mitogen-activated protein kinase 13
Gene Symbol
Mapk13
ORF Size (aa)
1101
ORF Size (bp)
1101 bp
RefSeq ID
NM_011950
RefSeq Synonyms
NM_011950, BC001992,
Species
mouse
UniGene ID
Mm.27970
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About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.