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mouse MADD shRNA silencing AAV

Name 
AAV-m-MADD-shRNA
Cat No 
shAAV-264076
Availability
4-5 weeks
Categories
AAV, shRNA-Silencing

This is an AAV expressing shRNA for silencing of Mouse MADD.

shAAV-264076
AAV-m-MADD-shRNA

Ready-to-use AAV expressing shRNA for silencing of Mouse MADD (MAP-kinase activating death domain). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype
Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
AAV ITR
AAV2
Promoter
U6 ()
Reporter
eGFP (default), optional CFP, YFP, RFP, mCherry
shRNA Knockdown (%)
62
Storage Buffer
PBS/5% Glycerol
Viral Backbone
Recombinant AAV

Gene Reference Data

Alternate Names
9630059K23Rik; IG20;
Description (Vector)
Plays a significant role in regulating cell proliferation, survival and death through alternative mRNA splicing. Isoform 5 shows increased cell proliferation and isoform 2 shows decreased. Converts GDP-bound inactive form of RAB3A, RAB3C and RAB3D to the GTP-bound active forms. Component of the TNFRSF1A signaling complex: MADD links TNFRSF1A with MAP kinase activation. Plays an important regulatory role in physiological cell death (TNF-alpha-induced, caspase-mediated apoptosis); isoform 1 is susceptible to inducing apoptosis, isoform 5 is resistant and isoform 3 and isoform 4 have no effect.
Gene ID
228355
Gene Name (Vector)
MAP-kinase activating death domain
Gene Symbol
MADD
ORF Size (aa)
4677
ORF Size (bp)
4677 bp
RefSeq ID
NM_145527
RefSeq Synonyms
NM_145527, NM_001177729, NM_001177728, NM_001177727, NM_001177726, NM_001177725, NM_001177724, NM_001177723, NM_001177722, NM_001177721, NM_001177720, NM_001177719, BC063386,
Species
mouse
UniGene ID
Mm.36410

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.