mouse ZNRF1 shRNA silencing AAV
This is an AAV expressing shRNA for silencing of Mouse Znrf1.
shAAV-263353
AAV-m-ZNRF1-shRNA
Ready-to-use AAV expressing shRNA for silencing of Mouse Znrf1 (zinc and ring finger 1). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
B830022L21Rik; nin283; Rnf42; Zrfp1
Description (Vector)
E3 ubiquitin-protein ligase that mediates the ubiquitination of AKT1 and GLUL, thereby playing a role in neuron cells differentiation. Plays a role in the establishment and maintenance of neuronal transmission and plasticity. Regulates Schwann cells differentiation by mediating ubiquitination of GLUL. Promotes neurodegeneration by mediating 'Lys-48'-linked polyubiquitination and subsequent degradation of AKT1 in axons: degradation of AKT1 prevents AKT1-mediated phosphorylation of GSK3B, leading to GSK3B activation and phosphorylation of DPYSL2/CRMP2 followed by destabilization of microtubule assembly in axons (Probable).
Gene ID
170737
Gene Name (Vector)
zinc and ring finger 1
Gene Symbol
Znrf1
ORF Size (aa)
684
ORF Size (bp)
684 bp
RefSeq ID
NM_133206
RefSeq Synonyms
NM_133206, NM_001168623, NM_001168622, NM_001168621, BC086770, BC006765,
Species
mouse
UniGene ID
Mm.271578
About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.