mouse LAT shRNA silencing AAV
This is an AAV expressing shRNA for silencing of Mouse Lat.
shAAV-263274
AAV-m-LAT-shRNA
Ready-to-use AAV expressing shRNA for silencing of Mouse Lat (linker for activation of T cells). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
p36-38; pp36
Description (Vector)
Required for TCR (T-cell antigen receptor)- and pre-TCR-mediated signaling, both in mature T-cells and during their development. Involved in FCGR3 (low affinity immunoglobulin gamma Fc region receptor III)-mediated signaling in natural killer cells and FCER1 (high affinity immunoglobulin epsilon receptor)-mediated signaling in mast cells. Couples activation of these receptors and their associated kinases with distal intracellular events such as mobilization of intracellular calcium stores, PKC activation, MAPK activation or cytoskeletal reorganization through the recruitment of PLCG1, GRB2, GRAP2, and other signaling molecules.
Gene ID
16797
Gene Name (Vector)
linker for activation of T cells
Gene Symbol
Lat
ORF Size (aa)
729
RefSeq ID
NM_010689
RefSeq Synonyms
NM_010689, BC052340, BC013337,
Species
mouse
UniGene ID
Mm.10280
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About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.