mouse LAG3 shRNA silencing AAV

Name 
AAV-m-LAG3-shRNA
Cat No 
shAAV-263224
Availability
6-8 weeks
Categories
AAV, shRNA-Silencing

This is an AAV expressing shRNA for silencing of Mouse Lag3.

shAAV-263224
AAV-m-LAG3-shRNA

Ready-to-use AAV expressing shRNA for silencing of Mouse Lag3 (lymphocyte-activation gene 3). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype
Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
AAV ITR
AAV2
Promoter
U6 ()
Reporter
eGFP (default), optional CFP, YFP, RFP, mCherry
Storage Buffer
PBS/5% Glycerol
Viral Backbone
Recombinant AAV

Gene Reference Data

Alternate Names
CD antigen CD223;CD223;LAG-3;Ly66;lymphocyte activation gene 3 protein
Description (eCommerce)
Lymphocyte-activation protein 3 belongs to Ig superfamily and contains 4 extracellular Ig-like domains. The LAG3 gene contains 8 exons. The sequence data, exon/intron organization, and chromosomal localization all indicate a close relationship of LAG3 to CD4 [taken from NCBI Entrez Gene (Gene ID: 3902)]
Description (Vector)
Involved in lymphocyte activation. Binds to HLA class-II antigens.
Gene ID
16768
Gene Name (eCommerce)
lymphocyte-activation gene 3
Gene Name (Vector)
lymphocyte-activation gene 3
Gene Symbol
Lag3
NCBI Taxonomy ID (eCommerce)
10090.0
ORF Size (aa)
1566
ORF Size (bp)
1566 bp
Protein Name (eCommerce)
Lymphocyte activation gene 3 protein
RefSeq ID
NM_008479
RefSeq Synonyms
NM_008479, BC120591,
Research Areas
Immune cells & tumor markers,Immune-checkpoints,Immunology,Immuno-Oncology,Signal Transduction,T cell markers
Research Areas (Faceted)
immuno_oncology,immunology,signal_transduction
Species
mouse
Target Sentence
Lymphocyte-activation protein 3 belongs to Ig superfamily and contains 4 extracellular Ig-like domains. The LAG3 gene contains 8 exons. The sequence data, exon/intron organization, and chromosomal localization all indicate a close relationship of LAG3 to CD4 [taken from NCBI Entrez Gene (Gene ID: 3902)]
UniGene ID
Mm.4528
UniProt ID (eCommerce)
Q61790

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.