mouse KLK6 shRNA silencing AAV
This is an AAV expressing shRNA for silencing of Mouse Klk6.
shAAV-262969
AAV-m-KLK6-shRNA
Ready-to-use AAV expressing shRNA for silencing of Mouse Klk6 (kallikrein related-peptidase 6). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
AI849898; BSP; Bssp; Klk29; MSP; neurosin; Prss18; Prss9
Description (Vector)
Serine protease which exhibits a preference for Arg over Lys in the substrate P1 position and for Ser or Pro in the P2 position. Shows activity against amyloid precursor protein, myelin basic protein, gelatin, casein and extracellular matrix proteins such as fibronectin, laminin, vitronectin and collagen. Degrades alpha-synuclein and prevents its polymerization, indicating that it may be involved in the pathogenesis of Parkinson disease and other synucleinopathies. May be involved in regulation of axon outgrowth following spinal cord injury. Tumor cells treated with a neutralizing KLK6 antibody migrate less than control cells, suggesting a role in invasion and metastasis.
Gene ID
19144
Gene Name (Vector)
kallikrein related-peptidase 6
Gene Symbol
Klk6
ORF Size (aa)
762
RefSeq ID
NM_011177
RefSeq Synonyms
NM_011177, NM_001164698, NM_001164697, NM_001164696, BC031119,
Species
mouse
UniGene ID
Mm.3944
About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.